Therapeutic Efficacy of 2-Methoxyestradiol Microcrystals Encapsulated within Polyelectrolyte Multilayers
نویسندگان
چکیده
منابع مشابه
Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers.
Development of a novel formulation of anticancer drugs to improve their water-solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2-methoxyestradiol (2-ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer-by-layer deposition of oppositely charged PEs onto the drug microcrystal surfaces. Cell viability...
متن کاملCellular immobilization within microfluidic microenvironments: dielectrophoresis with polyelectrolyte multilayers.
The development of biomimetic microenvironments will improve cell culture techniques by enabling in vitro cell cultures that mimic in vivo behavior; however, experimental control over attachment, cellular position, or intercellular distances within such microenvironments remains challenging. We report here the rapid and controllable immobilization of suspended mammalian cells within microfabric...
متن کاملResponsive polyelectrolyte multilayers
Responsive polyelectrolyte multilayers Karine Glinel a,∗, Christophe Déjugnat b,1, Michelle Prevot b, Björn Schöler a, Monika Schönhoff c, Regine v. Klitzing d a Laboratoire Polymères, Biopolymères, Membranes, UMR 6522 CNRS, Université de Rouen, F-76821 Mont-Saint-Aignan, France b Max Planck Institute of Colloids and Interfaces, Am Mühlenberg, D-14424 Potsdam, Germany c Institute of Physical Ch...
متن کاملMechanical properties of nanotubes of polyelectrolyte multilayers.
The elastic properties of nanotubes fabricated by layer-by-layer (LbL) assembly of polyelectrolytes in the nanopores of polycarbonate track-etched membranes have been investigated by resonant contact Atomic Force Microscopy (AFM), for nanotube diameters in the range of 100 to 200 nm. The elastic modulus of the nanotubes was computed from the resonance frequencies of a cantilever resting on free...
متن کاملPatterned Microstructure Fabrication: Polyelectrolyte Complexes vs Polyelectrolyte Multilayers
Polyelectrolyte complexes (PEC) are formed by mixing the solutions of oppositely charged polyelectrolytes, which were hitherto deemed "impossible" to process, since they are infusible and brittle when dry. Here, we describe the process of fabricating free-standing micro-patterned PEC films containing array of hollow or filled microchambers by one-step casting with small applied pressure and a P...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Macromolecular Bioscience
سال: 2009
ISSN: 1616-5187
DOI: 10.1002/mabi.200800381